| 11.12.20162016-12-11 15:15:00 | 15:15 | Premier League | 15. R |
Southampton - Middlesbrough
| -:- | St. Mary's StadiumBritannia RoadSouthampton,S014 5FPGB |
| 8.12.20162016-12-8 21:05:00 | 21:05 | Europa League Grp. K | 6. R |
Southampton - Hapoel Beer Sheva
| -:- | St. Mary's StadiumBritannia RoadSouthampton,S014 5FPGB |
| 3.12.20162016-12-3 16:00:00 | 16:00 | Premier League | 14. R |
Crystal Palace - Southampton
| 3:0 (2:0) | Selhurst ParkHolmesdale RoadLondon,SE25 6PUGB |
| 30.11.20162016-11-30 20:45:00 | 20:45 | EFL Cup | 5. R |
Arsenal - Southampton
| 0:2 (0:2) | Emirates StadiumQueensland RoadLondon,N7 7AJGB |
| 27.11.20162016-11-27 17:30:00 | 17:30 | Premier League | 13. R |
Southampton - Everton
| 1:0 (1:0) | St. Mary's StadiumBritannia RoadSouthampton,S014 5FPGB |
| 24.11.20162016-11-24 19:00:00 | 19:00 | Europa League Grp. K | 5. R |
Sparta Prag - Southampton
| 1:0 (1:0) | Generali ArenaFischhofgasse 12Wien,1100AT |
| 19.11.20162016-11-19 16:00:00 | 16:00 | Premier League | 12. R |
Southampton - Liverpool
| 0:0 (0:0) | St. Mary's StadiumBritannia RoadSouthampton,S014 5FPGB |
| 6.11.20162016-11-6 15:15:00 | 15:15 | Premier League | 11. R |
Hull City - Southampton
| 2:1 (0:1) |
