| 3.12.20162016-12-3 18:30:00 | 18:30 | 1. Bundesliga | 13. R | RasenBallsport Leipzig - Schalke 04 | 2:1 (1:1) |
| 27.11.20162016-11-27 15:30:00 | 15:30 | 1. Bundesliga | 12. R | Schalke 04 - Darmstadt | 3:1 (1:1) |
| 24.11.20162016-11-24 19:00:00 | 19:00 | Europa League Grp. I | 5. R | Schalke 04 - OGC Nizza | 2:0 (1:0) |
| 19.11.20162016-11-19 15:30:00 | 15:30 | 1. Bundesliga | 11. R | VFL Wolfsburg - Schalke 04 | 0:1 (0:0) |
| 6.11.20162016-11-6 17:30:00 | 17:30 | 1. Bundesliga | 10. R | Schalke 04 - Werder Bremen | 3:1 (2:1) |
| 3.11.20162016-11-3 21:05:00 | 21:05 | Europa League Grp. I | 4. R | Schalke 04 - FC Krasnodar | 2:0 (2:0) |
| 24.11.20162016-11-24 17:00:00 | 17:00 | Europa League Grp. B | 5. R | FC Astana - APOEL Nikosia | 2:1 (0:1) |
| 3.11.20162016-11-3 19:00:00 | 19:00 | Europa League Grp. B | 4. R | APOEL Nikosia - BSC Young Boys | 1:0 (0:0) |
| 20.10.20162016-10-20 21:05:00 | 21:05 | Europa League Grp. B | 3. R | BSC Young Boys - APOEL Nikosia | 3:1 (1:1) |
| 29.9.20162016-9-29 21:05:00 | 21:05 | Europa League Grp. B | 2. R | Olympiacos - APOEL Nikosia | 0:1 (0:1) |
| 15.9.20162016-9-15 19:00:00 | 19:00 | Europa League Grp. B | 1. R | APOEL Nikosia - FC Astana | 2:1 (0:1) |
| 24.8.20162016-8-24 20:45:00 | 20:45 | Champions League Qualification | Finale | APOEL Nikosia - FC Kopenhagen | 1:1 (0:0) |