| 11.12.20162016-12-11 17:30:00 | 17:30 | 1. Bundesliga | 14. R | Schalke 04 - Bayer Leverkusen | -:- |
| 7.12.20162016-12-7 20:45:00 | 20:45 | Champions League grp. E | 6. R | Bayer Leverkusen - Monaco | -:- |
| 3.12.20162016-12-3 15:30:00 | 15:30 | 1. Bundesliga | 13. R | Bayer Leverkusen - Freiburg | 1:1 (0:1) |
| 26.11.20162016-11-26 18:30:00 | 18:30 | 1. Bundesliga | 12. R | Bayern München - Bayer Leverkusen | 2:1 (1:1) |
| 22.11.20162016-11-22 18:00:00 | 18:00 | Champions League grp. E | 5. R | ZSKA Moskau - Bayer Leverkusen | 1:1 (0:1) |
| 18.11.20162016-11-18 20:30:00 | 20:30 | 1. Bundesliga | 11. R | Bayer Leverkusen - RasenBallsport Leipzig | 2:3 (2:1) |
| 5.11.20162016-11-5 15:30:00 | 15:30 | 1. Bundesliga | 10. R | Bayer Leverkusen - Darmstadt | 3:2 (1:0) |
| 2.11.20162016-11-2 20:45:00 | 20:45 | Champions League grp. E | 4. R | Tottenham Hotspur - Bayer Leverkusen | 0:1 (0:0) |
| 6.12.20162016-12-6 20:45:00 | 20:45 | Champions League grp. B | 6. R | Dynamo Kiew - Besiktas | -:- |
| 3.12.20162016-12-3 17:00:00 | 17:00 | Super Lig | 13. R | Fenerbahce - Besiktas | 0:0 (0:0) |
| 29.11.20162016-11-29 18:30:00 | 18:30 | Cup grp. D | 1. R | Darica Genclerbirligi - Besiktas | 1:2 (0:0) |
| 26.11.20162016-11-26 17:00:00 | 17:00 | Super Lig | 12. R | Besiktas - Istanbul Basaksehir | 1:1 (0:1) |
| 23.11.20162016-11-23 18:45:00 | 18:45 | Champions League grp. B | 5. R | Besiktas - Benfica | 3:3 (0:3) |
| 19.11.20162016-11-19 17:00:00 | 17:00 | Super Lig | 11. R | Adanaspor - Besiktas | 1:2 (0:2) |
| 5.11.20162016-11-5 17:00:00 | 17:00 | Super Lig | 10. R | Besiktas - Trabzonspor | 2:1 (2:1) |