| 11.12.20162016-12-11 17:30:00 | 17:30 | 1. Bundesliga | 14. R | Schalke 04 - Bayer Leverkusen | -:- |
| 7.12.20162016-12-7 20:45:00 | 20:45 | Champions League grp. E | 6. R | Bayer Leverkusen - Monaco | -:- |
| 3.12.20162016-12-3 15:30:00 | 15:30 | 1. Bundesliga | 13. R | Bayer Leverkusen - Freiburg | 1:1 (0:1) |
| 26.11.20162016-11-26 18:30:00 | 18:30 | 1. Bundesliga | 12. R | Bayern München - Bayer Leverkusen | 2:1 (1:1) |
| 22.11.20162016-11-22 18:00:00 | 18:00 | Champions League grp. E | 5. R | ZSKA Moskau - Bayer Leverkusen | 1:1 (0:1) |
| 18.11.20162016-11-18 20:30:00 | 20:30 | 1. Bundesliga | 11. R | Bayer Leverkusen - RasenBallsport Leipzig | 2:3 (2:1) |
| 5.11.20162016-11-5 15:30:00 | 15:30 | 1. Bundesliga | 10. R | Bayer Leverkusen - Darmstadt | 3:2 (1:0) |
| 2.11.20162016-11-2 20:45:00 | 20:45 | Champions League grp. E | 4. R | Tottenham Hotspur - Bayer Leverkusen | 0:1 (0:0) |
| 8.12.20162016-12-8 19:00:00 | 19:00 | Europa League Grp. B | 6. R | APOEL Nikosia - Olympiacos | -:- |
| 24.11.20162016-11-24 21:05:00 | 21:05 | Europa League Grp. B | 5. R | Olympiacos - BSC Young Boys | 1:1 (0:0) |
| 3.11.20162016-11-3 17:00:00 | 17:00 | Europa League Grp. B | 4. R | FC Astana - Olympiacos | 1:1 (1:1) |
| 20.10.20162016-10-20 21:05:00 | 21:05 | Europa League Grp. B | 3. R | Olympiacos - FC Astana | 4:1 (3:0) |
| 29.9.20162016-9-29 21:05:00 | 21:05 | Europa League Grp. B | 2. R | Olympiacos - APOEL Nikosia | 0:1 (0:1) |
| 15.9.20162016-9-15 19:00:00 | 19:00 | Europa League Grp. B | 1. R | BSC Young Boys - Olympiacos | 0:1 (0:1) |
| 25.8.20162016-8-25 20:45:00 | 20:45 | Europa League Qualification | Finale | Olympiacos - Arouca | 2:1 (0:0) |