| 11.12.20162016-12-11 17:30:00 | 17:30 | 1. Bundesliga | 14. R | Schalke 04 - Bayer Leverkusen | -:- |
| 7.12.20162016-12-7 20:45:00 | 20:45 | Champions League grp. E | 6. R | Bayer Leverkusen - Monaco | -:- |
| 3.12.20162016-12-3 15:30:00 | 15:30 | 1. Bundesliga | 13. R | Bayer Leverkusen - Freiburg | 1:1 (0:1) |
| 26.11.20162016-11-26 18:30:00 | 18:30 | 1. Bundesliga | 12. R | Bayern München - Bayer Leverkusen | 2:1 (1:1) |
| 22.11.20162016-11-22 18:00:00 | 18:00 | Champions League grp. E | 5. R | ZSKA Moskau - Bayer Leverkusen | 1:1 (0:1) |
| 18.11.20162016-11-18 20:30:00 | 20:30 | 1. Bundesliga | 11. R | Bayer Leverkusen - RasenBallsport Leipzig | 2:3 (2:1) |
| 5.11.20162016-11-5 15:30:00 | 15:30 | 1. Bundesliga | 10. R | Bayer Leverkusen - Darmstadt | 3:2 (1:0) |
| 2.11.20162016-11-2 20:45:00 | 20:45 | Champions League grp. E | 4. R | Tottenham Hotspur - Bayer Leverkusen | 0:1 (0:0) |
| 12.12.20162016-12-12 21:00:00 | 21:00 | Serie A | 16. R | AS Rom - AC Milan | -:- |
| 8.12.20162016-12-8 19:00:00 | 19:00 | Europa League Grp. E | 6. R | Astra Giurgiu - AS Rom | -:- |
| 4.12.20162016-12-4 15:00:00 | 15:00 | Serie A | 15. R | Lazio Rom - AS Rom | 0:2 (0:0) |
| 27.11.20162016-11-27 20:45:00 | 20:45 | Serie A | 14. R | AS Rom - Pescara Calcio | 3:2 (2:0) |
| 24.11.20162016-11-24 21:05:00 | 21:05 | Europa League Grp. E | 5. R | AS Rom - Viktoria Pilsen | 4:1 (1:1) |
| 20.11.20162016-11-20 15:00:00 | 15:00 | Serie A | 13. R | Atalanta Bergamo - AS Rom | 2:1 (0:1) |
| 6.11.20162016-11-6 20:45:00 | 20:45 | Serie A | 12. R | AS Rom - FC Bologna | 3:0 (1:0) |
| 3.11.20162016-11-3 19:00:00 | 19:00 | Europa League Grp. E | 4. R | Austria Wien - AS Rom | 2:4 (1:2) |